Norepinephrine depletion impairs motor recovery following sensorimotor cortex injury in the rat.


Journal Article

Beam-walking in the rat provides a method for investigating the effects of drugs on motor recovery following unilateral injury to the sensorimotor cortex. In the present experiment, the impact of norepinephrine depletion on beam-walking recovery was investigated. Groups of rats were first given either the neurotoxin DSP-4 or saline. Two weeks later, the animals were trained at the beam-walking task. Rats were then subjected to either a unilateral sensorimotor cortex lesion or sham operation. Recovery of beam-walking performance was measured over the next 12 days. Pretreatment with DSP-4 significantly slowed the rate of recovery but did not significantly affect sham-operated rats. Norepinephrine was significantly diminished in both lesioned and sham-operated rats that had been given DSP-4. These results are consistent with the hypothesis that recovery of beam-walking in the rat is mediated, at least in part, through noradrenergic neurons.

Full Text

Duke Authors

Cited Authors

  • Goldstein, LB; Coviello, A; Miller, GD; Davis, JN

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 41 - 47

PubMed ID

  • 21551632

Pubmed Central ID

  • 21551632

International Standard Serial Number (ISSN)

  • 0922-6028

Digital Object Identifier (DOI)

  • 10.3233/RNN-1991-3105


  • eng

Conference Location

  • Netherlands