Drosophila, genetic screens, and cardiac function.

Published

Journal Article (Review)

The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offer new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.

Full Text

Duke Authors

Cited Authors

  • Wolf, MJ; Rockman, HA

Published Date

  • September 2011

Published In

Volume / Issue

  • 109 / 7

Start / End Page

  • 794 - 806

PubMed ID

  • 21921272

Pubmed Central ID

  • 21921272

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

International Standard Serial Number (ISSN)

  • 0009-7330

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.111.244897

Language

  • eng