Drosophila melanogaster as a model system for genetics of postnatal cardiac function.


Journal Article

The fruit fly, Drosophila melanogaster, is an excellent model system that has a vast set of molecular tools and mutants to dissect the genetic pathways that are responsible for the normal and abnormal cardiac function. While the majority of studies have focused on heart development in the Drosophila embryo, attention has recently focused on the structure and function of the adult fly heart as a model of human heart failure. Here we review strategies to identify novel genes and pathways that cause or modify dilated cardiomyopathy in adult Drosophila.

Full Text

Duke Authors

Cited Authors

  • Wolf, MJ; Rockman, HA

Published Date

  • October 1, 2008

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 117 - 123

PubMed ID

  • 19802348

Pubmed Central ID

  • 19802348

International Standard Serial Number (ISSN)

  • 1740-6757

Digital Object Identifier (DOI)

  • 10.1016/j.ddmod.2009.02.002


  • eng

Conference Location

  • Netherlands