The clinical management of chondrosarcoma.

Journal Article (Journal Article;Review)

OPINION STATEMENT: Chondrosarcomas (CHS) represent a heterogeneous group of disorders ranging from indolent, low-grade tumors to aggressive, high-grade forms. Surgical resection represents the primary and preferred treatment modality for individuals with localized disease. Radiation therapy is appropriate for the treatment of positive surgical margins or palliation of disease-related symptoms. The treatment of advanced, metastatic disease is particularly challenging given the recognition that conventional chemotherapy has proven to be largely ineffective. Systemic chemotherapy may be considered in variant forms such as mesenchymal or dedifferentiated chondrosarcomas but high-quality data supporting its use is limited. There is universal agreement, however, that novel treatment strategies are desperately needed. This review will highlight the need for a coordinated multidisciplinary approach to optimize the management and care of patients.

Full Text

Duke Authors

Cited Authors

  • Riedel, RF; Larrier, N; Dodd, L; Kirsch, D; Martinez, S; Brigman, BE

Published Date

  • April 2009

Published In

Volume / Issue

  • 10 / 1-2

Start / End Page

  • 94 - 106

PubMed ID

  • 19238552

Electronic International Standard Serial Number (EISSN)

  • 1534-6277

Digital Object Identifier (DOI)

  • 10.1007/s11864-009-0088-2


  • eng

Conference Location

  • United States