NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.

Journal Article (Journal Article)

The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting.

Full Text

Duke Authors

Cited Authors

  • Demetri, GD; von Mehren, M; Antonescu, CR; DeMatteo, RP; Ganjoo, KN; Maki, RG; Pisters, PWT; Raut, CP; Riedel, RF; Schuetze, S; Sundar, HM; Trent, JC; Wayne, JD

Published Date

  • April 2010

Published In

Volume / Issue

  • 8 Suppl 2 /

Start / End Page

  • S1 - 41

PubMed ID

  • 20457867

Pubmed Central ID

  • PMC4103754

International Standard Serial Number (ISSN)

  • 1540-1405

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2010.0116


  • eng

Conference Location

  • United States