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NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.

Publication ,  Journal Article
Demetri, GD; von Mehren, M; Antonescu, CR; DeMatteo, RP; Ganjoo, KN; Maki, RG; Pisters, PWT; Raut, CP; Riedel, RF; Schuetze, S; Sundar, HM ...
Published in: J Natl Compr Canc Netw
April 2010

The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting.

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Published In

J Natl Compr Canc Netw

DOI

ISSN

1540-1405

Publication Date

April 2010

Volume

8 Suppl 2

Issue

0 2

Start / End Page

S1 / 41

Location

United States

Related Subject Headings

  • Sunitinib
  • Pyrroles
  • Pyrimidines
  • Prognosis
  • Piperazines
  • Oncology & Carcinogenesis
  • Indoles
  • Imatinib Mesylate
  • Humans
  • Gene Expression Profiling
 

Citation

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Demetri, G. D., von Mehren, M., Antonescu, C. R., DeMatteo, R. P., Ganjoo, K. N., Maki, R. G., … Wayne, J. D. (2010). NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw, 8 Suppl 2(0 2), S1-41. https://doi.org/10.6004/jnccn.2010.0116
Demetri, George D., Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W. T. Pisters, et al. “NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.J Natl Compr Canc Netw 8 Suppl 2, no. 0 2 (April 2010): S1-41. https://doi.org/10.6004/jnccn.2010.0116.
Demetri GD, von Mehren M, Antonescu CR, DeMatteo RP, Ganjoo KN, Maki RG, et al. NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2(0 2):S1-41.
Demetri, George D., et al. “NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.J Natl Compr Canc Netw, vol. 8 Suppl 2, no. 0 2, Apr. 2010, pp. S1-41. Pubmed, doi:10.6004/jnccn.2010.0116.
Demetri GD, von Mehren M, Antonescu CR, DeMatteo RP, Ganjoo KN, Maki RG, Pisters PWT, Raut CP, Riedel RF, Schuetze S, Sundar HM, Trent JC, Wayne JD. NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2(0 2):S1-41.

Published In

J Natl Compr Canc Netw

DOI

ISSN

1540-1405

Publication Date

April 2010

Volume

8 Suppl 2

Issue

0 2

Start / End Page

S1 / 41

Location

United States

Related Subject Headings

  • Sunitinib
  • Pyrroles
  • Pyrimidines
  • Prognosis
  • Piperazines
  • Oncology & Carcinogenesis
  • Indoles
  • Imatinib Mesylate
  • Humans
  • Gene Expression Profiling