Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.

Journal Article (Journal Article;Review)

β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of β-arrestin interactions and β-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of β-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of β-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling.

Full Text

Duke Authors

Cited Authors

  • Shukla, AK; Xiao, K; Lefkowitz, RJ

Published Date

  • September 2011

Published In

Volume / Issue

  • 36 / 9

Start / End Page

  • 457 - 469

PubMed ID

  • 21764321

Pubmed Central ID

  • PMC3168679

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2011.06.003


  • eng

Conference Location

  • England