Population genetics of neutral mutations in exponentially growing cancer cell populations

Published

Journal Article

In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or "driver," mutations from "passenger" mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population. © Institute of Mathematical Statistics, 2013.

Full Text

Duke Authors

Cited Authors

  • Durrett, R

Published Date

  • February 1, 2013

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 230 - 250

International Standard Serial Number (ISSN)

  • 1050-5164

Digital Object Identifier (DOI)

  • 10.1214/11-AAP824

Citation Source

  • Scopus