Conducting economic evaluations alongside multinational clinical trials: toward a research consensus.


Journal Article

Demand for economic evaluations in multinational clinical trials is increasing, but there is little consensus about how such studies should be conducted and reported. At a workshop in Durham, North Carolina, we sought to identify areas of agreement about how the primary findings of economic evaluations in multinational clinical trials should be generated and presented. In this paper, we propose a framework for classifying multinational economic evaluations according to (a) the sources of an analyst's estimates of resource use and clinical effectiveness and (b) the analyst's method of estimating costs. We review existing studies in the cardiology literature in the context of the proposed framework. We then describe important methodological and practical considerations in conducting multinational economic evaluations and summarize the advantages and disadvantages of each approach. Finally, we describe opportunities for future research. Delineation of the various approaches to multinational economic evaluation may assist researchers, peer reviewers, journal editors, and decision makers in evaluating the strengths and limitations of particular studies.

Full Text

Duke Authors

Cited Authors

  • Reed, SD; Anstrom, KJ; Bakhai, A; Briggs, AH; Califf, RM; Cohen, DJ; Drummond, MF; Glick, HA; Gnanasakthy, A; Hlatky, MA; O'Brien, BJ; Torti, FM; Tsiatis, AA; Willan, AR; Mark, DB; Schulman, KA

Published Date

  • March 2005

Published In

Volume / Issue

  • 149 / 3

Start / End Page

  • 434 - 443

PubMed ID

  • 15864231

Pubmed Central ID

  • 15864231

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2004.11.001


  • eng

Conference Location

  • United States