Clopidogrel use and bleeding after coronary artery bypass graft surgery.
BACKGROUND: Short-term use of clopidogrel plus aspirin among patients with acute coronary syndrome reduces ischemic events, but concerns about coronary artery bypass graft (CABG) surgery-related bleeding limit its early use. METHODS: Using data from 4,794 consecutive CABG procedures in the Duke Databank for Cardiovascular Disease (January 1999 to December 2003), we developed multivariable models for associations with CABG-related bleeding defined as reoperation for bleeding, red cell transfusion, and a composite of reoperation/transfusion/hematocrit drop>or=15%. We examined clopidogrel use
Kim, JH-J; Newby, LK; Clare, RM; Shaw, LK; Lodge, AJ; Smith, PK; Jolicoeur, EM; Rao, SV; Becker, RC; Mark, DB; Granger, CB
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