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Cardiac resynchronization therapy: Part 1--issues before device implantation.

Publication ,  Journal Article
Bax, JJ; Abraham, T; Barold, SS; Breithardt, OA; Fung, JWH; Garrigue, S; Gorcsan, J; Hayes, DL; Kass, DA; Knuuti, J; Leclercq, C; Linde, C ...
Published in: J Am Coll Cardiol
December 20, 2005

Cardiac resynchronization therapy (CRT) has been used extensively over the last years in the therapeutic management of patients with end-stage heart failure. Data from 4,017 patients have been published in eight large, randomized trials on CRT. Improvement in clinical end points (symptoms, exercise capacity, quality of life) and echocardiographic end points (systolic function, left ventricular size, mitral regurgitation) have been reported after CRT, with a reduction in hospitalizations for decompensated heart failure and an improvement in survival. However, individual results vary, and 20% to 30% of patients do not respond to CRT. At present, the selection criteria include severe heart failure (New York Heart Association functional class III or IV), left ventricular ejection fraction <35%, and wide QRS complex (>120 ms). Assessment of inter- and particularly intraventricular dyssynchrony as provided by echocardiography (predominantly tissue Doppler imaging techniques) may allow improved identification of potential responders to CRT. In this review a summary of the clinical and echocardiographic results of the large, randomized trials is provided, followed by an extensive overview on the currently available echocardiographic techniques for assessment of LV dyssynchrony. In addition, the value of LV scar tissue and venous anatomy for the selection of potential candidates for CRT are discussed.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

December 20, 2005

Volume

46

Issue

12

Start / End Page

2153 / 2167

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Patient Selection
  • Pacemaker, Artificial
  • Humans
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial
  • Cardiac Output, Low
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
 

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Bax, J. J., Abraham, T., Barold, S. S., Breithardt, O. A., Fung, J. W. H., Garrigue, S., … Yu, C.-M. (2005). Cardiac resynchronization therapy: Part 1--issues before device implantation. J Am Coll Cardiol, 46(12), 2153–2167. https://doi.org/10.1016/j.jacc.2005.09.019
Bax, Jeroen J., Theodore Abraham, S Serge Barold, Ole A. Breithardt, Jeffrey W. H. Fung, Stephane Garrigue, John Gorcsan, et al. “Cardiac resynchronization therapy: Part 1--issues before device implantation.J Am Coll Cardiol 46, no. 12 (December 20, 2005): 2153–67. https://doi.org/10.1016/j.jacc.2005.09.019.
Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JWH, Garrigue S, et al. Cardiac resynchronization therapy: Part 1--issues before device implantation. J Am Coll Cardiol. 2005 Dec 20;46(12):2153–67.
Bax, Jeroen J., et al. “Cardiac resynchronization therapy: Part 1--issues before device implantation.J Am Coll Cardiol, vol. 46, no. 12, Dec. 2005, pp. 2153–67. Pubmed, doi:10.1016/j.jacc.2005.09.019.
Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JWH, Garrigue S, Gorcsan J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu C-M. Cardiac resynchronization therapy: Part 1--issues before device implantation. J Am Coll Cardiol. 2005 Dec 20;46(12):2153–2167.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

December 20, 2005

Volume

46

Issue

12

Start / End Page

2153 / 2167

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Patient Selection
  • Pacemaker, Artificial
  • Humans
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial
  • Cardiac Output, Low
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services