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A three-factor analytic model of the MADRS in geriatric depression.

Publication ,  Journal Article
Parker, RD; Flint, EP; Bosworth, HB; Pieper, CF; Steffens, DC
Published in: Int J Geriatr Psychiatry
January 2003

OBJECTIVE: Major depression is a heterogeneous disorder, perhaps comprising several clinical subtypes or subgroups of symptoms. This study examined whether items on the Montgomery-Asberg Depression Rating Scale (MADRS) form distinct symptom subgroups among geriatric depressive patients that might form the basis of new outcome measures for tracking treatment effects. METHOD: The study examined a sample of 225 adults age 59 and older diagnosed with major depression. Factor analysis with oblique rotation was used to analyze baseline MADRS item scores. RESULTS: Three distinct interpretable factors were obtained; all ten items loaded <0.60 on a domain. The first factor, dysphoric apathy/retardation, comprised five items: apparent sadness, reported sadness, lassitude, reduced concentration, and inability to feel. Psychic anxiety, the second factor, included three items: inner tension, pessimistic thoughts, and suicidal thoughts. The third factor, vegetative symptoms, resulted from items involving sleep and appetite. CONCLUSIONS: The study produced three interpretable MADRS factors reflecting geriatric depression dimensions that may be useable to monitor focused treatment outcomes.

Duke Scholars

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

January 2003

Volume

18

Issue

1

Start / End Page

73 / 77

Location

England

Related Subject Headings

  • Treatment Outcome
  • Sleep Wake Disorders
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Humans
  • Geriatrics
  • Geriatric Assessment
  • Factor Analysis, Statistical
  • Depressive Disorder
  • Anxiety
 

Citation

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ICMJE
MLA
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Parker, R. D., Flint, E. P., Bosworth, H. B., Pieper, C. F., & Steffens, D. C. (2003). A three-factor analytic model of the MADRS in geriatric depression. Int J Geriatr Psychiatry, 18(1), 73–77. https://doi.org/10.1002/gps.776
Parker, R. D., Elizabeth P. Flint, Hayden B. Bosworth, Carl F. Pieper, and David C. Steffens. “A three-factor analytic model of the MADRS in geriatric depression.Int J Geriatr Psychiatry 18, no. 1 (January 2003): 73–77. https://doi.org/10.1002/gps.776.
Parker RD, Flint EP, Bosworth HB, Pieper CF, Steffens DC. A three-factor analytic model of the MADRS in geriatric depression. Int J Geriatr Psychiatry. 2003 Jan;18(1):73–7.
Parker, R. D., et al. “A three-factor analytic model of the MADRS in geriatric depression.Int J Geriatr Psychiatry, vol. 18, no. 1, Jan. 2003, pp. 73–77. Pubmed, doi:10.1002/gps.776.
Parker RD, Flint EP, Bosworth HB, Pieper CF, Steffens DC. A three-factor analytic model of the MADRS in geriatric depression. Int J Geriatr Psychiatry. 2003 Jan;18(1):73–77.
Journal cover image

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

January 2003

Volume

18

Issue

1

Start / End Page

73 / 77

Location

England

Related Subject Headings

  • Treatment Outcome
  • Sleep Wake Disorders
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Humans
  • Geriatrics
  • Geriatric Assessment
  • Factor Analysis, Statistical
  • Depressive Disorder
  • Anxiety