Emotional processing in anterior cingulate and medial prefrontal cortex.

Published

Journal Article (Review)

Negative emotional stimuli activate a broad network of brain regions, including the medial prefrontal (mPFC) and anterior cingulate (ACC) cortices. An early influential view dichotomized these regions into dorsal-caudal cognitive and ventral-rostral affective subdivisions. In this review, we examine a wealth of recent research on negative emotions in animals and humans, using the example of fear or anxiety, and conclude that, contrary to the traditional dichotomy, both subdivisions make key contributions to emotional processing. Specifically, dorsal-caudal regions of the ACC and mPFC are involved in appraisal and expression of negative emotion, whereas ventral-rostral portions of the ACC and mPFC have a regulatory role with respect to limbic regions involved in generating emotional responses. Moreover, this new framework is broadly consistent with emerging data on other negative and positive emotions.

Full Text

Duke Authors

Cited Authors

  • Etkin, A; Egner, T; Kalisch, R

Published Date

  • February 2011

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 85 - 93

PubMed ID

  • 21167765

Pubmed Central ID

  • 21167765

Electronic International Standard Serial Number (EISSN)

  • 1879-307X

International Standard Serial Number (ISSN)

  • 1364-6613

Digital Object Identifier (DOI)

  • 10.1016/j.tics.2010.11.004

Language

  • eng