Sleep deprivation biases the neural mechanisms underlying economic preferences.

Journal Article (Journal Article)

A single night of sleep deprivation (SD) evoked a strategy shift during risky decision making such that healthy human volunteers moved from defending against losses to seeking increased gains. This change in economic preferences was correlated with the magnitude of an SD-driven increase in ventromedial prefrontal activation as well as by an SD-driven decrease in anterior insula activation during decision making. Analogous changes were observed during receipt of reward outcomes: elevated activation to gains in ventromedial prefrontal cortex and ventral striatum, but attenuated anterior insula activation following losses. Finally, the observed shift in economic preferences was not correlated with change in psychomotor vigilance. These results suggest that a night of total sleep deprivation affects the neural mechanisms underlying economic preferences independent of its effects on vigilant attention.

Full Text

Duke Authors

Cited Authors

  • Venkatraman, V; Huettel, SA; Chuah, LYM; Payne, JW; Chee, MWL

Published Date

  • March 2011

Published In

Volume / Issue

  • 31 / 10

Start / End Page

  • 3712 - 3718

PubMed ID

  • 21389226

Pubmed Central ID

  • PMC6622793

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.4407-10.2011


  • eng