Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1.

Journal Article (Journal Article;Review)

In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia".

Full Text

Duke Authors

Cited Authors

  • Mayeux, R; Reitz, C; Brickman, AM; Haan, MN; Manly, JJ; Glymour, MM; Weiss, CC; Yaffe, K; Middleton, L; Hendrie, HC; Warren, LH; Hayden, KM; Welsh-Bohmer, KA; Breitner, JCS; Morris, JC

Published Date

  • January 2011

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 15 - 34

PubMed ID

  • 21255741

Pubmed Central ID

  • PMC3063444

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2010.11.005


  • eng

Conference Location

  • United States