Phase II study of carboplatin (CBDCA) in refractory multiple myeloma. A Southwest Oncology Group study.


Journal Article

Nineteen patients with multiple myeloma resistant to standard alkylating agent therapy or to the VAD regimen received carboplatin at a planned daily dose of 100 mg/M2 on four successive days. Two patients erroneously received a four-fold higher drug dose resulting in bone marrow aplasia and death without antitumor effect in one patient with post-mortem examination. No anti-tumor effect was observed among 15 patients evaluable for response (two lacked follow-up examination of tumor markers). Major toxicities were hematologic and included grade > or = III, leukopenia in 9, thrombocytopenia in 6 and anemia in 3 of the 17 evaluable patients. Their median survival was 9 months. These results indicate that carboplatin is inactive in refractory multiple myeloma.

Full Text

Cited Authors

  • Barlogie, B; Crowley, J; Salmon, SE; Bonnet, J; Weick, JK; Hayden, K

Published Date

  • January 1994

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 53 - 55

PubMed ID

  • 7960607

Pubmed Central ID

  • 7960607

Electronic International Standard Serial Number (EISSN)

  • 1573-0646

International Standard Serial Number (ISSN)

  • 0167-6997

Digital Object Identifier (DOI)

  • 10.1007/bf00873237


  • eng