Plasma adiponectin increases postprandially in obese, but not in lean, subjects.


Journal Article

OBJECTIVE: We investigated the acute responses of plasma adiponectin levels to a test meal in lean and obese subjects. RESEARCH METHODS AND PROCEDURES: We studied 13 lean and 11 obese subjects after a 10-hour overnight fast. Glucose, insulin, and adiponectin concentrations were measured at baseline and 15, 30, 60, 120, and 180 minutes after a fixed breakfast. RESULTS: At baseline, fasting adiponectin concentrations were lower in the obese group vs. the lean group [mean (95% confidence interval): 2.9 (2.1 to 4.1) microg/mL vs. 8.6 (6.5 to 11.3) microg/mL], but rose 4-fold postprandially in the obese group, reaching a peak at 60 minutes [baseline: 2.9 (2.1 to 4.1) microg/mL vs. 60 minutes: 12.1 (8.5 to 17.4) microg/mL; p< 0.0001] and remaining elevated for the remainder of the study. There were no postprandial changes in plasma adiponectin concentrations in lean subjects. DISCUSSION: This increase of adiponectin concentrations in obese individuals might have important beneficial effects on postprandial glucose and lipid metabolism and might be viewed as a mechanism for maintaining normal glucose tolerance in those who are obese and insulin resistant.

Full Text

Cited Authors

  • English, PJ; Coughlin, SR; Hayden, K; Malik, IA; Wilding, JPH

Published Date

  • July 2003

Published In

Volume / Issue

  • 11 / 7

Start / End Page

  • 839 - 844

PubMed ID

  • 12855752

Pubmed Central ID

  • 12855752

International Standard Serial Number (ISSN)

  • 1071-7323

Digital Object Identifier (DOI)

  • 10.1038/oby.2003.115


  • eng

Conference Location

  • United States