Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.

Journal Article (Journal Article;Review)

Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

Full Text

Duke Authors

Cited Authors

  • Dworkin, RH; Backonja, M; Rowbotham, MC; Allen, RR; Argoff, CR; Bennett, GJ; Bushnell, MC; Farrar, JT; Galer, BS; Haythornthwaite, JA; Hewitt, DJ; Loeser, JD; Max, MB; Saltarelli, M; Schmader, KE; Stein, C; Thompson, D; Turk, DC; Wallace, MS; Watkins, LR; Weinstein, SM

Published Date

  • November 2003

Published In

Volume / Issue

  • 60 / 11

Start / End Page

  • 1524 - 1534

PubMed ID

  • 14623723

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.60.11.1524


  • eng

Conference Location

  • United States