Assessment of pain in herpes zoster: lessons learned from antiviral trials.


Journal Article (Review)

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster.

Full Text

Duke Authors

Cited Authors

  • Dworkin, RH; Carrington, D; Cunningham, A; Kost, RG; Levin, MJ; McKendrick, MW; Oxman, MN; Rentier, B; Schmader, KE; Tappeiner, G; Wassilew, SW; Whitley, RJ

Published Date

  • January 1997

Published In

Volume / Issue

  • 33 / 2

Start / End Page

  • 73 - 85

PubMed ID

  • 9021049

Pubmed Central ID

  • 9021049

International Standard Serial Number (ISSN)

  • 0166-3542

Digital Object Identifier (DOI)

  • 10.1016/s0166-3542(96)01007-8


  • eng

Conference Location

  • Netherlands