Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department.

Journal Article (Journal Article)

OBJECTIVES: To determine whether suboptimal pharmacotherapy increases the risk of adverse outcomes in older adults discharged from the emergency department (ED). DESIGN: Retrospective, cohort study. SETTING: Academically affiliated Veterans Affairs Medical Center. PARTICIPANTS: Nine hundred forty-two veterans aged 65 and older discharged from the ED. MEASUREMENTS: The primary independent variable, suboptimal pharmacotherapy, was based on drugs-to-avoid criteria, drug-drug interactions, drug-disease interactions, or failure to satisfy explicit quality indicators (QIs). An adverse outcome was defined as one or more repeat ED visits or hospitalizations or death within 90 days of ED discharge. RESULTS: Four hundred twenty-one patients were prescribed a new medication at ED discharge. Of these, 134 (31.8%) had suboptimal pharmacotherapy; 49 (11.6%) were prescribed a drug to avoid, 53 (12.6%) received a drug that introduced a new drug-drug interaction, 24 (5.7%) were given a drug that introduced a drug-disease interaction, and 74 (17.6%) did not have a QI satisfied. Overall, 320 patients (34.0%) experienced an adverse outcome within 90 days. Multivariable analyses suggested a trend toward greater risk of adverse outcomes in patients with suboptimal pharmacotherapy (hazard ratio=1.32, 95% confidence interval=0.95, 1.84). CONCLUSION: A substantial number of older male veterans discharged from the ED may be at risk for adverse events due to suboptimal prescribing and inadequate medication monitoring. Efforts to improve the quality of pharmacotherapy in this vulnerable population are warranted.

Full Text

Duke Authors

Cited Authors

  • Hastings, SN; Schmader, KE; Sloane, RJ; Weinberger, M; Pieper, CF; Goldberg, KC; Oddone, EZ

Published Date

  • May 2008

Published In

Volume / Issue

  • 56 / 5

Start / End Page

  • 875 - 880

PubMed ID

  • 18341519

Electronic International Standard Serial Number (EISSN)

  • 1532-5415

Digital Object Identifier (DOI)

  • 10.1111/j.1532-5415.2008.01648.x


  • eng

Conference Location

  • United States