Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine.

Journal Article

Both 2,6-cis- and 2,6-trans-piperidines were prepared from common substrates through organocatalytic aza-Michael reactions promoted by the gem-disubstituent effect in conjunction with dithiane coupling reactions. The organocatalytic aza-Michael reaction enabled a facile synthesis of (+)-myrtine and (-)-epimyrtine from a common substrate.

Full Text

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Duke Authors

Hong, Jiyong

Cited Authors

Ying, Y; Kim, H; Hong, J

Published Date

February 2011

Published In

Organic Letters

Volume / Issue

13 / 4

Start / End Page

796 - 799

PubMed ID

21250755

Pubmed Central ID

21250755

Electronic International Standard Serial Number (EISSN)

1523-7052

International Standard Serial Number (ISSN)

1523-7060

Digital Object Identifier (DOI)

10.1021/ol103064f

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