Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine.
Journal Article
Both 2,6-cis- and 2,6-trans-piperidines were prepared from common substrates through organocatalytic aza-Michael reactions promoted by the gem-disubstituent effect in conjunction with dithiane coupling reactions. The organocatalytic aza-Michael reaction enabled a facile synthesis of (+)-myrtine and (-)-epimyrtine from a common substrate.
Full Text
Duke Authors
Cited Authors
- Ying, Y; Kim, H; Hong, J
Published Date
- February 2011
Published In
Volume / Issue
- 13 / 4
Start / End Page
- 796 - 799
PubMed ID
- 21250755
Pubmed Central ID
- 21250755
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/ol103064f
Language
- eng