Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.

Published online

Journal Article

Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (T(FH) cells). In contrast, tissue type 2 helper T cells (T(H)2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) produced IL-13. IL-13 production by T(H)2 and Ih2 cells was dependent on the transcription factor GATA-3, which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in T(FH) cells and basophils. The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.

Full Text

Cited Authors

  • Liang, H-E; Reinhardt, RL; Bando, JK; Sullivan, BM; Ho, I-C; Locksley, RM

Published Date

  • December 4, 2011

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 58 - 66

PubMed ID

  • 22138715

Pubmed Central ID

  • 22138715

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/ni.2182

Language

  • eng

Conference Location

  • United States