Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.

Published

Journal Article

Peptide:MHC II complexes derived from a fluorescent antigen were detected in vivo to identify the cells that present subcutaneously injected antigen to CD4 T cells. Skin-derived dendritic cells (DCs) that acquired the antigen while in the draining lymph nodes were the first cells to display peptide:MHC II complexes. Presentation by these cells induced CD69, IL-2 production, and maximal proliferation by the T cells. Later, DCs displaying peptide:MHC II complexes migrated from the injection site via a G protein-dependent mechanism. Presentation by these migrants sustained expression of the IL-2 receptor and promoted delayed type hypersensitivity. Therefore, presentation of peptide:MHC II complexes derived from a subcutaneous antigen occurs in two temporally distinct waves with different functional consequences.

Full Text

Cited Authors

  • Itano, AA; McSorley, SJ; Reinhardt, RL; Ehst, BD; Ingulli, E; Rudensky, AY; Jenkins, MK

Published Date

  • July 2003

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 47 - 57

PubMed ID

  • 12871638

Pubmed Central ID

  • 12871638

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(03)00175-4

Language

  • eng

Conference Location

  • United States