Nanotechnology and tumor imaging: seizing an opportunity.

Published

Journal Article (Review)

Nanoparticles, labeled with a signaling moiety for in vivo imaging, and one or more ligands for molecularly targeted specificity, hold considerable promise in oncology. Nanoparticles can serve as modular platforms, from which a wide variety of highly sensitive and specific imaging agents can be created. For example, many hundreds or thousands of atoms that provide imaging signals, such as radioisotopes, lanthanides, or fluorophores, can be attached to each nanoparticle, to form imaging agents that would provide higher sensitivity that can be obtained from agents based on small molecules. Similarly, many copies of targeted ligands can be attached to nanoparticles to markedly increase specific binding. Drugs or therapeutic isotopes can be added to create multifunctional nanoparticles. Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex.

Full Text

Duke Authors

Cited Authors

  • Sullivan, DC; Ferrari, M

Published Date

  • October 2004

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 364 - 369

PubMed ID

  • 15802054

Pubmed Central ID

  • 15802054

International Standard Serial Number (ISSN)

  • 1535-3508

Digital Object Identifier (DOI)

  • 10.1162/1535350042973526

Language

  • eng

Conference Location

  • United States