Meeting report: high-throughput technologies for in vivo imaging agents.
Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vivo imaging agents. Important differences in the biological and pharmacological properties needed for imaging agents, compared to those for a therapeutic agent, require new screening methods that emphasize those characteristics, such as optimized residence time and tissue specificity, that make for a good imaging agent candidate.
Gillies, RJ; Hoffman, JM; Lam, KS; Menkens, AE; Piwnica-Worms, DR; Sullivan, DC; Weissleder, R
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