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The natural history of mammographic calcifications subjected to interval follow-up.

Publication ,  Journal Article
Berend, ME; Sullivan, DC; Kornguth, PJ; Skinner, CS; Ost, A; Iglehart, JD; Skinner, MA
Published in: Arch Surg
November 1992

The purpose of this investigation was to determine the natural history and risk of malignancy associated with isolated indeterminate microcalcifications subjected to interval follow-up. During a 2-year study, 91 patients were identified with indeterminate microcalcifications alone. Specific roentgenographic features of the calcifications were evaluated on initial and follow-up mammograms. During a mean follow-up of 36 months, 19 (21%) of the women exhibited mammographic changes. Ten patients (11%) with suspicious changes underwent a needle-directed biopsy 6 to 30 months after the initial mammographic screening. Five women (5.5%) were diagnosed as having breast carcinoma; three had invasive ductal carcinoma and two had purely intraductal lesions. Four patients had axillary lymph node dissections and no metastatic disease was found. We found no significant differences in the roentgenographic features associated with malignant vs benign lesions apart from an increased overall estimation of the probability of malignancy rating in the five patients with breast carcinoma. We recommend that patients be followed up with mammography at regular intervals for at least 18 months following recognition of indeterminate microcalcifications.

Duke Scholars

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

November 1992

Volume

127

Issue

11

Start / End Page

1309 / 1313

Location

United States

Related Subject Headings

  • Surgery
  • Risk Factors
  • Predictive Value of Tests
  • Neoplasm Staging
  • Middle Aged
  • Mammography
  • Incidence
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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MLA
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Berend, M. E., Sullivan, D. C., Kornguth, P. J., Skinner, C. S., Ost, A., Iglehart, J. D., & Skinner, M. A. (1992). The natural history of mammographic calcifications subjected to interval follow-up. Arch Surg, 127(11), 1309–1313. https://doi.org/10.1001/archsurg.1992.01420110055012
Berend, M. E., D. C. Sullivan, P. J. Kornguth, C. S. Skinner, A. Ost, J. D. Iglehart, and M. A. Skinner. “The natural history of mammographic calcifications subjected to interval follow-up.Arch Surg 127, no. 11 (November 1992): 1309–13. https://doi.org/10.1001/archsurg.1992.01420110055012.
Berend ME, Sullivan DC, Kornguth PJ, Skinner CS, Ost A, Iglehart JD, et al. The natural history of mammographic calcifications subjected to interval follow-up. Arch Surg. 1992 Nov;127(11):1309–13.
Berend, M. E., et al. “The natural history of mammographic calcifications subjected to interval follow-up.Arch Surg, vol. 127, no. 11, Nov. 1992, pp. 1309–13. Pubmed, doi:10.1001/archsurg.1992.01420110055012.
Berend ME, Sullivan DC, Kornguth PJ, Skinner CS, Ost A, Iglehart JD, Skinner MA. The natural history of mammographic calcifications subjected to interval follow-up. Arch Surg. 1992 Nov;127(11):1309–1313.

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

November 1992

Volume

127

Issue

11

Start / End Page

1309 / 1313

Location

United States

Related Subject Headings

  • Surgery
  • Risk Factors
  • Predictive Value of Tests
  • Neoplasm Staging
  • Middle Aged
  • Mammography
  • Incidence
  • Humans
  • Follow-Up Studies
  • Female