Antibacterial activity of synthetic fire ant venom: the solenopsins and isosolenopsins.

Published

Journal Article

BACKGROUND: We determined the in vitro activity of 9 synthetic fire ant venom alkaloids (+/-)-solenopsin A, (2R, 6R)-solenopsin A, (2S, 6S)-solenopsin B, (+/-)-isosolenopsin A, (2S, 6R)-isosolenopsin A,(2R, 6S)-isosolenopsin A, (+/-)-isosolenopsin B, (2S, 6R)-isosolenopsin B, and (2R, 6S)-isosolenopsin B against 6 species of bacteria (Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Stenotrophomonas maltophilia, and Pseudomonas aeruginosa). METHODS: The minimum inhibitory concentration and minimum bacteriocidal concentration were determined in accordance with the Clinical Laboratory Standards Institute guidelines. Time kill studies used American Type Culture Collection bacterial isolates tested at 5 times the minimum inhibitory concentration. RESULTS: None of the venom alkaloids inhibited E. coli or P. aeruginosa, whereas all the alkaloids inhibited S. pneumoniae. Only 4 alkaloids inhibited S. pneumoniae, S. aureus, and S. maltophilia. Time-kill kinetics indicates that all 4 active alkaloids had bactericidal activity. CONCLUSIONS: Specific isomers of synthetic fire ant venom alkaloids have antibacterial activity against human pathogens.

Full Text

Cited Authors

  • Sullivan, DC; Flowers, H; Rockhold, R; Herath, HMTB; Nanayakkara, NPD

Published Date

  • October 2009

Published In

Volume / Issue

  • 338 / 4

Start / End Page

  • 287 - 291

PubMed ID

  • 19826319

Pubmed Central ID

  • 19826319

Electronic International Standard Serial Number (EISSN)

  • 1538-2990

International Standard Serial Number (ISSN)

  • 0002-9629

Digital Object Identifier (DOI)

  • 10.1097/maj.0b013e3181af8270

Language

  • eng