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Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium.

Publication ,  Journal Article
Gupta, RT; Marin, D; Boll, DT; Husarik, DB; Davis, DE; Feuerlein, S; Merkle, EM
Published in: Eur J Radiol
October 2012

PURPOSE: To compare intraindividual differences in enhancement pattern of hepatic hemangiomas between gadobenate dimeglumine (Gd-BOPTA) and gadoxetate disodium (Gd-EOB-DTPA)-enhanced 3T MR imaging. MATERIALS AND METHODS: This is a HIPAA-compliant, IRB-approved retrospective study with waiver for informed consent granted. From 10/07 to 5/09, 10 patients (2 males, 8 females; mean age, 57.3 years) with 15 hepatic hemangiomas (mean diameter, 4.4 ± 5.6 cm) underwent both Gd-BOPTA- and Gd-EOB-DTPA-enhanced 3T MR imaging (mean interval, 266 days; range, 38-462 days). Diagnosis of hemangioma was based on strict imaging criteria. MR imaging was obtained during three arterial, portal venous, and up to four delayed phases. During each phase, hemangioma-to-liver contrast-to-noise ratio (CNR) was measured for each lesion on both examinations. Statistical analysis was performed using paired Student's t-test. RESULTS: Hemangioma-to-liver CNR peaked during the portal venous phase (Gd-BOPTA: 48.9 ± 65.8, Gd-EOB-DTPA: 0.7 ± 3.8). During all imaging phases except the first arterial phase, hemangioma-to-liver CNR was significantly lower on Gd-EOB-DTPA-enhanced compared to Gd-BOPTA-enhanced MR images (p<0.05). Notably, Gd-EOB-DTPA yielded negative hemangioma-to-liver CNR (-2.5 ± 2.4) compared to Gd-BOPTA (40.7 ± 56.4) during the first delayed phase (7-8 min after contrast administration), remaining negative for the rest of the delayed phases (up to 26 min after contrast administration). CONCLUSION: The enhancement patterns of hepatic hemangiomas differs significantly between Gd-BOPTA and Gd-EOB-DTPA-enhanced 3T MR imaging. The smaller dose, shorter plasma half-life, and increased hepatobiliary uptake of Gd-EOB-DTPA leads to a negative CNR of hemangioma-to-liver on delayed phases and could create an imaging pitfall with this agent.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

October 2012

Volume

81

Issue

10

Start / End Page

2457 / 2462

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Enhancement
 

Citation

APA
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ICMJE
MLA
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Gupta, R. T., Marin, D., Boll, D. T., Husarik, D. B., Davis, D. E., Feuerlein, S., & Merkle, E. M. (2012). Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium. Eur J Radiol, 81(10), 2457–2462. https://doi.org/10.1016/j.ejrad.2011.10.014
Gupta, Rajan T., Daniele Marin, Daniel T. Boll, Daniela B. Husarik, Drew E. Davis, Sebastian Feuerlein, and Elmar M. Merkle. “Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium.Eur J Radiol 81, no. 10 (October 2012): 2457–62. https://doi.org/10.1016/j.ejrad.2011.10.014.
Gupta RT, Marin D, Boll DT, Husarik DB, Davis DE, Feuerlein S, et al. Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium. Eur J Radiol. 2012 Oct;81(10):2457–62.
Gupta, Rajan T., et al. “Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium.Eur J Radiol, vol. 81, no. 10, Oct. 2012, pp. 2457–62. Pubmed, doi:10.1016/j.ejrad.2011.10.014.
Gupta RT, Marin D, Boll DT, Husarik DB, Davis DE, Feuerlein S, Merkle EM. Hepatic hemangiomas: difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium. Eur J Radiol. 2012 Oct;81(10):2457–2462.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

October 2012

Volume

81

Issue

10

Start / End Page

2457 / 2462

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Enhancement