Reconstructing regulatory network transitions.
Journal Article (Review;Journal Article)
Cellular responses often involve a transition of cells from one state to another. A transition from a stem cell to a differentiated cell state, for example, might occur in response to gene expression changes induced by a transcription factor, or to signaling cascades triggered by a hormone or pathogen. Regulatory networks are thought to control such cellular transitions. Thus, many researchers are interested in reconstructing regulatory networks, not only with the aim of gaining a deeper understanding of cellular transitions, but also of using networks to predict and potentially manipulate cellular transitions and outcomes. In this review, we highlight approaches to the reconstruction of regulatory networks underlying cellular transitions, with special attention to transcriptional regulatory networks. We describe recent regulatory network reconstructions in a variety of organisms, and discuss the success they share in identifying new regulatory components, shared relationships and phenotypic outcomes.
Full Text
Duke Authors
Cited Authors
- Petricka, JJ; Benfey, PN
Published Date
- August 2011
Published In
Volume / Issue
- 21 / 8
Start / End Page
- 442 - 451
PubMed ID
- 21632251
Pubmed Central ID
- PMC3149721
Electronic International Standard Serial Number (EISSN)
- 1879-3088
International Standard Serial Number (ISSN)
- 0962-8924
Digital Object Identifier (DOI)
- 10.1016/j.tcb.2011.05.001
Language
- eng