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Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye.

Publication ,  Journal Article
Mah, FS; O'Brien, T; Kim, T; Torkildsen, G
Published in: Curr Med Res Opin
February 2008

PURPOSE: Olopatadine hydrochloride 0.2% (Pataday, Alcon, Fort Worth, USA) is a topical ocular anti-allergic agent that has shown high rates of efficacy in treating ocular itching, the primary symptom of allergic conjunctivitis, and allows for once-daily dosing. Since some patients suffer from signs or symptoms of dry eye in addition to ocular allergy, this study was designed to evaluate the safety of olopatadine 0.2% in a population of patients with both allergic conjunctivitis and dry eye. METHODS: This was a single-center, 3-visit, double-masked, randomized study. Fifty-two patients diagnosed with ocular allergy and mild-to-moderate dry eye were evaluated. After a run-in period, patients were randomized to receive either olopatadine hydrochloride 0.2% or a tear saline, and self-dosed once-daily for 1 week. Outcome measures included tear film break-up time, corneal and conjunctival staining, tear volume and flow as measured by fluorophotometry, Schirmer's test, injection, and symptom evaluations. RESULTS: No significant differences between the treatment groups were observed (p > 0.05). No serious adverse events occurred during the trial. Variability in the presentation of dry eye can hinder the observation of treatment effects. Although the study design facilitated the comparison of olopatadine 0.2% against an agent that was certain to not exacerbate dry eye, future comparison of olopatadine 0.2% against other agents in its drug class would provide useful information about relative drug tolerabilities. CONCLUSION: As there were no significant changes in the signs and symptoms of dry eye, olopatadine hydrochloride 0.2% is safe to use in ocular allergy patients with mild-to-moderate dry eye.

Duke Scholars

Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

February 2008

Volume

24

Issue

2

Start / End Page

441 / 447

Location

England

Related Subject Headings

  • Treatment Outcome
  • Sodium Chloride
  • Ophthalmic Solutions
  • Olopatadine Hydrochloride
  • Middle Aged
  • Male
  • Humans
  • Health Status Indicators
  • General & Internal Medicine
  • Female
 

Citation

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Mah, F. S., O’Brien, T., Kim, T., & Torkildsen, G. (2008). Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye. Curr Med Res Opin, 24(2), 441–447. https://doi.org/10.1185/030079908x261078
Mah, F. S., T. O’Brien, T. Kim, and G. Torkildsen. “Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye.Curr Med Res Opin 24, no. 2 (February 2008): 441–47. https://doi.org/10.1185/030079908x261078.
Mah, F. S., et al. “Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye.Curr Med Res Opin, vol. 24, no. 2, Feb. 2008, pp. 441–47. Pubmed, doi:10.1185/030079908x261078.

Published In

Curr Med Res Opin

DOI

EISSN

1473-4877

Publication Date

February 2008

Volume

24

Issue

2

Start / End Page

441 / 447

Location

England

Related Subject Headings

  • Treatment Outcome
  • Sodium Chloride
  • Ophthalmic Solutions
  • Olopatadine Hydrochloride
  • Middle Aged
  • Male
  • Humans
  • Health Status Indicators
  • General & Internal Medicine
  • Female