Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.

Journal Article (Journal Article)

A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.

Full Text

Duke Authors

Cited Authors

  • Wathier, M; Johnson, CS; Kim, T; Grinstaff, MW

Published Date

  • 2006

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 873 - 876

PubMed ID

  • 16848392

International Standard Serial Number (ISSN)

  • 1043-1802

Digital Object Identifier (DOI)

  • 10.1021/bc060060f


  • eng

Conference Location

  • United States