Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
Wathier, M; Johnson, CS; Kim, T; Grinstaff, MW
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