In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.

Published

Journal Article

OBJECTIVE: To determine if a biodendrimer adhesive will seal a clear corneal cataract incision. DESIGN: An experimental study in which 2.75-mm clear corneal cataract incisions were made in 8 human donor eyes. The corneas were mounted on an artificial anterior chamber. Leaking pressure was determined in 6 corneas. These corneas were then treated with adhesive and leaking pressure was again measured in 4 of them. India ink was then applied to the 2 remaining treated and the 2 untreated corneas. Chamber pressure was cycled between 100 and 0 mm Hg. Optical coherence tomography was used to visualize the wound dynamics of a ninth cornea treated with adhesive, mounted, and pressure cycled in a similar fashion. RESULTS: The mean (SD) leaking pressure was 77 (14) mm Hg for the nonsealed wounds and 142 (22) mm Hg for the adhesive-sealed wounds. india ink entered the nonsealed wounds and anterior chamber when the intraocular pressure was cyclically raised and lowered, whereas no india ink entered the adhesive-sealed wounds. The optical coherence tomography-visualized corneal wound did gape under pressure cycling, but the adhesive remained intact and stretched to conform to the wound. CONCLUSIONS: Biodendrimer adhesives may be used to seal cataract wounds to prevent leakage and influx of fluid.

Full Text

Duke Authors

Cited Authors

  • Johnson, CS; Wathier, M; Grinstaff, M; Kim, T

Published Date

  • April 2009

Published In

Volume / Issue

  • 127 / 4

Start / End Page

  • 430 - 434

PubMed ID

  • 19365019

Pubmed Central ID

  • 19365019

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

Digital Object Identifier (DOI)

  • 10.1001/archophthalmol.2009.46

Language

  • eng

Conference Location

  • United States