In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.
Journal Article
OBJECTIVE: To determine if a biodendrimer adhesive will seal a clear corneal cataract incision. DESIGN: An experimental study in which 2.75-mm clear corneal cataract incisions were made in 8 human donor eyes. The corneas were mounted on an artificial anterior chamber. Leaking pressure was determined in 6 corneas. These corneas were then treated with adhesive and leaking pressure was again measured in 4 of them. India ink was then applied to the 2 remaining treated and the 2 untreated corneas. Chamber pressure was cycled between 100 and 0 mm Hg. Optical coherence tomography was used to visualize the wound dynamics of a ninth cornea treated with adhesive, mounted, and pressure cycled in a similar fashion. RESULTS: The mean (SD) leaking pressure was 77 (14) mm Hg for the nonsealed wounds and 142 (22) mm Hg for the adhesive-sealed wounds. india ink entered the nonsealed wounds and anterior chamber when the intraocular pressure was cyclically raised and lowered, whereas no india ink entered the adhesive-sealed wounds. The optical coherence tomography-visualized corneal wound did gape under pressure cycling, but the adhesive remained intact and stretched to conform to the wound. CONCLUSIONS: Biodendrimer adhesives may be used to seal cataract wounds to prevent leakage and influx of fluid.
Full Text
Duke Authors
Cited Authors
- Johnson, CS; Wathier, M; Grinstaff, M; Kim, T
Published Date
- April 2009
Published In
Volume / Issue
- 127 / 4
Start / End Page
- 430 - 434
PubMed ID
- 19365019
Pubmed Central ID
- 19365019
Electronic International Standard Serial Number (EISSN)
- 1538-3601
Digital Object Identifier (DOI)
- 10.1001/archophthalmol.2009.46
Language
- eng
Conference Location
- United States