Hybrid dendritic-linear polyester-ethers for in situ photopolymerization.

Journal Article (Journal Article)

Novel first through fourth generation hybrid dendritic-linear copolymers, composed entirely of building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described. Specifically, these copolymers are composed of poly(ethylene glycol), glycerol, and succinic acid and are synthesized using a divergent approach in high yield. A photo-cross-linkable derivative of this copolymer successfully seals 4.1 mm corneal lacerations. The mechanism of tissue repair is likely one of physical entrapment where an interpenetrating network (IPN) is formed between the cross-linked copolymer and the tissue.

Full Text

Duke Authors

Cited Authors

  • Carnahan, MA; Middleton, C; Kim, J; Kim, T; Grinstaff, MW

Published Date

  • May 15, 2002

Published In

Volume / Issue

  • 124 / 19

Start / End Page

  • 5291 - 5293

PubMed ID

  • 11996569

Pubmed Central ID

  • 11996569

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja025576y

Language

  • eng

Conference Location

  • United States