Hybrid dendritic-linear polyester-ethers for in situ photopolymerization.
Publication
, Journal Article
Carnahan, MA; Middleton, C; Kim, J; Kim, T; Grinstaff, MW
Published in: J Am Chem Soc
May 15, 2002
Novel first through fourth generation hybrid dendritic-linear copolymers, composed entirely of building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described. Specifically, these copolymers are composed of poly(ethylene glycol), glycerol, and succinic acid and are synthesized using a divergent approach in high yield. A photo-cross-linkable derivative of this copolymer successfully seals 4.1 mm corneal lacerations. The mechanism of tissue repair is likely one of physical entrapment where an interpenetrating network (IPN) is formed between the cross-linked copolymer and the tissue.
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Published In
J Am Chem Soc
DOI
ISSN
0002-7863
Publication Date
May 15, 2002
Volume
124
Issue
19
Start / End Page
5291 / 5293
Location
United States
Related Subject Headings
- Succinates
- Polymers
- Polyethylene Glycols
- Photochemistry
- Humans
- Glycerol
- General Chemistry
- Eye Injuries
- 40 Engineering
- 34 Chemical sciences
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Carnahan, M. A., Middleton, C., Kim, J., Kim, T., & Grinstaff, M. W. (2002). Hybrid dendritic-linear polyester-ethers for in situ photopolymerization. J Am Chem Soc, 124(19), 5291–5293. https://doi.org/10.1021/ja025576y
Carnahan, Michael A., Crystan Middleton, Jitek Kim, Terry Kim, and Mark W. Grinstaff. “Hybrid dendritic-linear polyester-ethers for in situ photopolymerization.” J Am Chem Soc 124, no. 19 (May 15, 2002): 5291–93. https://doi.org/10.1021/ja025576y.
Carnahan MA, Middleton C, Kim J, Kim T, Grinstaff MW. Hybrid dendritic-linear polyester-ethers for in situ photopolymerization. J Am Chem Soc. 2002 May 15;124(19):5291–3.
Carnahan, Michael A., et al. “Hybrid dendritic-linear polyester-ethers for in situ photopolymerization.” J Am Chem Soc, vol. 124, no. 19, May 2002, pp. 5291–93. Pubmed, doi:10.1021/ja025576y.
Carnahan MA, Middleton C, Kim J, Kim T, Grinstaff MW. Hybrid dendritic-linear polyester-ethers for in situ photopolymerization. J Am Chem Soc. 2002 May 15;124(19):5291–5293.
Published In
J Am Chem Soc
DOI
ISSN
0002-7863
Publication Date
May 15, 2002
Volume
124
Issue
19
Start / End Page
5291 / 5293
Location
United States
Related Subject Headings
- Succinates
- Polymers
- Polyethylene Glycols
- Photochemistry
- Humans
- Glycerol
- General Chemistry
- Eye Injuries
- 40 Engineering
- 34 Chemical sciences