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Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis.

Publication ,  Journal Article
Khishchenko, N; Allen, KD; Coffman, CJ; Kasarskis, EJ; Lindquist, JH; Morgenlander, JC; Norman, BB; Oddone, EZ; Rozear, MP; Sabet, A; Sams, L ...
Published in: Amyotroph Lateral Scler
2010

Our objective was to determine the interval from symptom onset to diagnosis, and to evaluate associated factors in a cohort of U.S. Veterans with motor neuron diseases. We retrospectively evaluated 1359 patients enrolled in the National Registry of Veterans with Amyotrophic Lateral Sclerosis (ALS). The main outcome measures were time from symptom onset to first diagnosis and to second opinion. Predictor variables included age at symptom onset, year of symptom onset, race, onset site, final diagnosis, number of diagnostic tests performed and clinical sites visited. Median time to first diagnosis was 11 months; median time to second opinion was two months. In a multivariable model, more recent calendar year of symptom onset, younger age, bulbar onset and a diagnosis of ALS versus non-ALS motor neuron disease were all significantly associated with a shorter time to first diagnosis. Later year of symptom onset and white race were significantly associated with a shorter time to second opinion. While the interval from symptom onset to diagnosis, and many of the associated factors are similar between our large cohort of U.S. Veterans with ALS and other smaller published cohorts, we found that the diagnostic interval among U.S. Veterans has significantly decreased over time.

Duke Scholars

Published In

Amyotroph Lateral Scler

DOI

EISSN

1471-180X

Publication Date

2010

Volume

11

Issue

1-2

Start / End Page

125 / 132

Location

England

Related Subject Headings

  • White People
  • Veterans
  • United States Department of Veterans Affairs
  • United States
  • Time Factors
  • Sex Distribution
  • Regression Analysis
  • Registries
  • Predictive Value of Tests
  • Neurology & Neurosurgery
 

Citation

APA
Chicago
ICMJE
MLA
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Khishchenko, N., Allen, K. D., Coffman, C. J., Kasarskis, E. J., Lindquist, J. H., Morgenlander, J. C., … Bedlack, R. S. (2010). Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler, 11(1–2), 125–132. https://doi.org/10.3109/17482960802572681
Khishchenko, Natan, Kelli D. Allen, Cynthia J. Coffman, Edward J. Kasarskis, Jennifer H. Lindquist, Joel C. Morgenlander, Barbara B. Norman, et al. “Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis.Amyotroph Lateral Scler 11, no. 1–2 (2010): 125–32. https://doi.org/10.3109/17482960802572681.
Khishchenko N, Allen KD, Coffman CJ, Kasarskis EJ, Lindquist JH, Morgenlander JC, et al. Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler. 2010;11(1–2):125–32.
Khishchenko, Natan, et al. “Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis.Amyotroph Lateral Scler, vol. 11, no. 1–2, 2010, pp. 125–32. Pubmed, doi:10.3109/17482960802572681.
Khishchenko N, Allen KD, Coffman CJ, Kasarskis EJ, Lindquist JH, Morgenlander JC, Norman BB, Oddone EZ, Rozear MP, Sabet A, Sams L, Bedlack RS. Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler. 2010;11(1–2):125–132.

Published In

Amyotroph Lateral Scler

DOI

EISSN

1471-180X

Publication Date

2010

Volume

11

Issue

1-2

Start / End Page

125 / 132

Location

England

Related Subject Headings

  • White People
  • Veterans
  • United States Department of Veterans Affairs
  • United States
  • Time Factors
  • Sex Distribution
  • Regression Analysis
  • Registries
  • Predictive Value of Tests
  • Neurology & Neurosurgery