Association between blood lead and the risk of amyotrophic lateral sclerosis.

Journal Article (Journal Article)

The authors conducted a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this association of bone turnover and genetic factors related to lead toxicokinetics. Blood lead, plasma biomarkers of bone formation (procollagen type 1 amino-terminal peptide (PINP)) and resorption (C-terminal telopeptides of type 1 collagen (CTX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured. Odds ratios and 95% confidence intervals for the association of blood lead with ALS were estimated with unconditional logistic regression after adjustment for age and bone turnover. Blood lead levels were higher among cases compared with controls (P < 0.0001, age adjusted). A doubling of blood lead was associated with a 1.9-fold increased risk of ALS (95% confidence interval: 1.3, 2.7) after adjustment for age and CTX. Additional adjustment for PINP did not alter the results. Significant lead-ALS associations were observed in substrata of PINP and CTX levels. The K59N polymorphism in the ALAD gene did not modify the lead-ALS association (P = 0.32). These results extend earlier findings by accounting for bone turnover in confirming the association between elevated blood lead level and higher risk of ALS.

Full Text

Duke Authors

Cited Authors

  • Fang, F; Kwee, LC; Allen, KD; Umbach, DM; Ye, W; Watson, M; Keller, J; Oddone, EZ; Sandler, DP; Schmidt, S; Kamel, F

Published Date

  • May 15, 2010

Published In

Volume / Issue

  • 171 / 10

Start / End Page

  • 1126 - 1133

PubMed ID

  • 20406759

Pubmed Central ID

  • PMC2877471

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

Digital Object Identifier (DOI)

  • 10.1093/aje/kwq063


  • eng

Conference Location

  • United States