Many, but not all, outcome studies support exclusion of female plasma from the blood supply.

Journal Article (Journal Article;Review)

Transfusion-related acute lung injury (TRALI) has been identified as the most common cause of transfusion-related death. Although extensive literature supports restrictions on female-donor plasma to reduce antibody-mediated TRALI, only a few outcome studies have assessed for effects of this change, and some, but not all, have endorsed the policy. A recent report even suggests poorer outcomes in cardiac surgery patients with a shift to male-donor-only plasma, raising concerns that TRALI alone, whether catastrophic or more survivable, is insufficient compared with broader measures, such as short-term mortality or long-term survival, as an end point to assess for overall improvements in patient care.

Full Text

Duke Authors

Cited Authors

  • Stafford-Smith, M; Lockhart, E; Bandarenko, N; Welsby, I

Published Date

  • October 2010

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 551 - 558

PubMed ID

  • 21083472

Electronic International Standard Serial Number (EISSN)

  • 1747-4094

Digital Object Identifier (DOI)

  • 10.1586/ehm.10.57


  • eng

Conference Location

  • England