Many, but not all, outcome studies support exclusion of female plasma from the blood supply.
Journal Article (Journal Article;Review)
Transfusion-related acute lung injury (TRALI) has been identified as the most common cause of transfusion-related death. Although extensive literature supports restrictions on female-donor plasma to reduce antibody-mediated TRALI, only a few outcome studies have assessed for effects of this change, and some, but not all, have endorsed the policy. A recent report even suggests poorer outcomes in cardiac surgery patients with a shift to male-donor-only plasma, raising concerns that TRALI alone, whether catastrophic or more survivable, is insufficient compared with broader measures, such as short-term mortality or long-term survival, as an end point to assess for overall improvements in patient care.
Full Text
Duke Authors
Cited Authors
- Stafford-Smith, M; Lockhart, E; Bandarenko, N; Welsby, I
Published Date
- October 2010
Published In
Volume / Issue
- 3 / 5
Start / End Page
- 551 - 558
PubMed ID
- 21083472
Electronic International Standard Serial Number (EISSN)
- 1747-4094
Digital Object Identifier (DOI)
- 10.1586/ehm.10.57
Language
- eng
Conference Location
- England