Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.

Journal Article (Journal Article)

The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22 years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n = 378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.

Full Text

Duke Authors

Cited Authors

  • Latendresse, SJ; Bates, JE; Goodnight, JA; Lansford, JE; Budde, JP; Goate, A; Dodge, KA; Pettit, GS; Dick, DM

Published Date

  • November 2011

Published In

Volume / Issue

  • 82 / 6

Start / End Page

  • 1797 - 1814

PubMed ID

  • 21883161

Pubmed Central ID

  • PMC3218245

Electronic International Standard Serial Number (EISSN)

  • 1467-8624

International Standard Serial Number (ISSN)

  • 0009-3920

Digital Object Identifier (DOI)

  • 10.1111/j.1467-8624.2011.01640.x


  • eng