Cell invasion through basement membrane: the anchor cell breaches the barrier.
Journal Article (Review;Journal Article)
Cell invasion through basement membrane (BM) is a specialized cellular behavior critical to many normal developmental events, immune surveillance, and cancer metastasis. A highly dynamic process, cell invasion involves a complex interplay between cell-intrinsic elements that promote the invasive phenotype, and cell-cell and cell-BM interactions that regulate the timing and targeting of BM transmigration. The intricate nature of these interactions has made it challenging to study cell invasion in vivo and model in vitro. Anchor cell invasion in Caenorhabditis elegans is emerging as an important experimental paradigm for comprehensive analysis of BM invasion, revealing the gene networks that specify invasive behavior and the interactions that occur at the cell-BM interface.
Full Text
Duke Authors
Cited Authors
- Hagedorn, EJ; Sherwood, DR
Published Date
- October 2011
Published In
Volume / Issue
- 23 / 5
Start / End Page
- 589 - 596
PubMed ID
- 21632231
Pubmed Central ID
- PMC3167953
Electronic International Standard Serial Number (EISSN)
- 1879-0410
International Standard Serial Number (ISSN)
- 0955-0674
Digital Object Identifier (DOI)
- 10.1016/j.ceb.2011.05.002
Language
- eng