Quinpirole-induced sensitization to noisy/sparse periodic input: temporal synchronization as a component of obsessive-compulsive disorder.


Journal Article

Quinpirole-sensitized rats were tested on a discrete-trials 40-s peak-interval procedure using lever pressing as the instrumental response. Although there was no evidence of rhythmical activity in lever pressing, periodic output was observed in a secondary response (food-cup entries) during the inter-trial interval following the delivery of reinforcement on fixed-interval trials, but not during unreinforced probe trials. This repetitive pattern of behavior with a 40-s period points to the primacy of reinforcement as a time marker and an increased tendency to synchronize to noisy and sparse periodic input as a result of reduced inhibitory control in cortico-striatal circuits following chronic quinpirole administration. Parallels between quinpirole-induced rhythmical behavior and the repetitive motor habits frequently observed in obsessive-compulsive disorder are discussed.

Full Text

Cited Authors

  • Gu, BM; Cheng, RK; Yin, B; Meck, WH

Published Date

  • April 2011

Published In

Volume / Issue

  • 179 /

Start / End Page

  • 143 - 150

PubMed ID

  • 21284954

Pubmed Central ID

  • 21284954

Electronic International Standard Serial Number (EISSN)

  • 1873-7544

International Standard Serial Number (ISSN)

  • 0306-4522

Digital Object Identifier (DOI)

  • 10.1016/j.neuroscience.2011.01.048


  • eng