Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.

Journal Article (Journal Article)

OBJECTIVE: Bronchiolitis obliterans syndrome is the major cause of long-term graft failure in lung transplant recipients and may be partially reversible if diagnosed early and treated. Diagnosis is difficult because findings of transbronchial biopsy are often negative in patients with early disease. We are investigating a novel MR ventilation agent, hyperpolarized 3He, for evaluating ventilatory abnormalities in lung transplant recipients with suspected bronchiolitis obliterans syndrome. CONCLUSION: In this preliminary study, the extent of ventilatory defects revealed on 3He-enhanced MR images correlated with severity of bronchiolitis obliterans syndrome using an established clinical grading system. This new technique may hold potential for diagnosing bronchiolitis obliterans syndrome in lung transplant recipients.

Full Text

Duke Authors

Cited Authors

  • McAdams, HP; Palmer, SM; Donnelly, LF; Charles, HC; Tapson, VF; MacFall, JR

Published Date

  • October 1999

Published In

Volume / Issue

  • 173 / 4

Start / End Page

  • 955 - 959

PubMed ID

  • 10511156

International Standard Serial Number (ISSN)

  • 0361-803X

Digital Object Identifier (DOI)

  • 10.2214/ajr.173.4.10511156


  • eng

Conference Location

  • United States