Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.

Journal Article (Journal Article)

In rabbits anesthetized with pentobarbital, the carotid arterial blood pressure and bilateral contractions of the gastrocnemius muscles due to electrical stimulation of the sciatic nerves were recorded. Intravenous administration of up to 1 ml of dimethyl sulfoxide/kg caused profound hypotension and eventually failure of neuromuscular transmission. Caution must be used in considering dimethyl sulfoxide as a solvent for drug administration.

Full Text

Duke Authors

Cited Authors

  • Domer, FR; Chihal, DM; Charles, HC

Published Date

  • February 1, 1977

Published In

Volume / Issue

  • 66 / 2

Start / End Page

  • 269 - 270

PubMed ID

  • 839427

International Standard Serial Number (ISSN)

  • 0022-3549

Digital Object Identifier (DOI)

  • 10.1002/jps.2600660234


  • eng

Conference Location

  • United States