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Quantification of diabetic macular edema.

Publication ,  Journal Article
Smith, RT; Lee, CM; Charles, HC; Farber, M; Cunha-Vaz, JG
Published in: Arch Ophthalmol
February 1987

In a cross-sectional study, 34 diabetic patients with clinically significant macular edema underwent visual acuity testing, stereo fundus photography (graded for retinal thickening and hard exudates), fluorescein angiography (evaluated for macular leakage and the outline of the foveal avascular zone [FAZ]), and vitreous fluorophotometry (whereby posterior penetration ratios were calculated). This last ratio provided the highest single correlation with visual acuity; next highest were patient age and FAZ grading. Multivariate regression confirmed that these three variables together best predicted visual acuity. Lesser correlations with acuity were obtained with angiographic leakage and fundus photography grading. Cross-correlations among all gradings showed that indicators of breakdown of the blood-retinal barrier, ie, fluorophotometry, angiographic leakage, and retinal thickening, were significantly correlated with each other, whereas FAZ grading was independent of all these factors and correlated only with acuity. By performing vitreous fluorophotometry and fluorescein angiography, it is possible to quantitate two major components of diabetic maculopathy: breakdown of the blood-retinal barrier and macular ischemia, both of which are highly correlated with visual acuity.

Duke Scholars

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

February 1987

Volume

105

Issue

2

Start / End Page

218 / 222

Location

United States

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Statistics as Topic
  • Photometry
  • Ophthalmology & Optometry
  • Middle Aged
  • Macula Lutea
  • Humans
  • Fundus Oculi
  • Fluorometry
 

Citation

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Smith, R. T., Lee, C. M., Charles, H. C., Farber, M., & Cunha-Vaz, J. G. (1987). Quantification of diabetic macular edema. Arch Ophthalmol, 105(2), 218–222. https://doi.org/10.1001/archopht.1987.01060020072032
Smith, R. T., C. M. Lee, H. C. Charles, M. Farber, and J. G. Cunha-Vaz. “Quantification of diabetic macular edema.Arch Ophthalmol 105, no. 2 (February 1987): 218–22. https://doi.org/10.1001/archopht.1987.01060020072032.
Smith RT, Lee CM, Charles HC, Farber M, Cunha-Vaz JG. Quantification of diabetic macular edema. Arch Ophthalmol. 1987 Feb;105(2):218–22.
Smith, R. T., et al. “Quantification of diabetic macular edema.Arch Ophthalmol, vol. 105, no. 2, Feb. 1987, pp. 218–22. Pubmed, doi:10.1001/archopht.1987.01060020072032.
Smith RT, Lee CM, Charles HC, Farber M, Cunha-Vaz JG. Quantification of diabetic macular edema. Arch Ophthalmol. 1987 Feb;105(2):218–222.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

February 1987

Volume

105

Issue

2

Start / End Page

218 / 222

Location

United States

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Statistics as Topic
  • Photometry
  • Ophthalmology & Optometry
  • Middle Aged
  • Macula Lutea
  • Humans
  • Fundus Oculi
  • Fluorometry