Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.


Journal Article

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

Full Text

Duke Authors

Cited Authors

  • Charles, HC; Lazeyras, F; Krishnan, KR; Boyko, OB; Payne, M; Moore, D

Published Date

  • November 1994

Published In

Volume / Issue

  • 18 / 7

Start / End Page

  • 1121 - 1127

PubMed ID

  • 7846284

Pubmed Central ID

  • 7846284

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/0278-5846(94)90115-5


  • eng

Conference Location

  • England