Quantification of contrast in clinical MR brain imaging at high magnetic field.

Journal Article (Journal Article)

The relative contrast between two tissues in a magnetic resonance (MR) image is shown to be quantifiable for any combination of pulse timing parameters, provided the intrinsic parameters are known. Based on multiple inversion-recovery and spin echo images, a region-of-interest T1, T2 and density analysis was conducted at 1.4T in selected patients with diagnosed neuropathology for various brain tissues. The resulting tissue parameters subsequently served to calculate the contrast-to-noise (C/N) ratio for typical tissue interfaces as a function of the operator-variable pulse timing parameters and the data were compared with the images. Although such calculations may be useful as a protocol selection aid, it is obvious that an optimized pulse protocol can only be established for a single tissue interface. The data also reveal that a T2-discriminating pulse sequence like Carr-Purcell-Meiboom-Gill with long repetition time, generally advocated as clinically most effective, may not always be ideal.

Full Text

Duke Authors

Cited Authors

  • Wehrli, FW; Breger, RK; MacFall, JR; Daniels, DL; Haughton, VM; Charles, HC; Williams, AL

Published Date

  • July 1985

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 360 - 369

PubMed ID

  • 4044176

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-198507000-00005


  • eng

Conference Location

  • United States