Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.

Journal Article (Journal Article)

Four patients with cystic fibrosis (CF) were examined with combined hyperpolarized helium 3-enhanced and conventional proton magnetic resonance (MR) imaging. After inhalation of the polarized 3He gas, single breath-hold, gradient-echo images (resonant frequency of 3He) were obtained to depict lung ventilation. Conventional T2-weighted fast spin-echo (hydrogen) images were also obtained to depict morphologic abnormalities. 3He images were successfully and reproducibly generated that showed both morphologic abnormalities and, often more extensive, ventilation abnormalities. 3He MR imaging may provide a method for evaluating progression of pulmonary disease in patients with CF.

Full Text

Duke Authors

Cited Authors

  • Donnelly, LF; MacFall, JR; McAdams, HP; Majure, JM; Smith, J; Frush, DP; Bogonad, P; Charles, HC; Ravin, CE

Published Date

  • September 1999

Published In

Volume / Issue

  • 212 / 3

Start / End Page

  • 885 - 889

PubMed ID

  • 10478261

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.212.3.r99se20885


  • eng

Conference Location

  • United States