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Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.

Publication ,  Journal Article
Donnelly, LF; MacFall, JR; McAdams, HP; Majure, JM; Smith, J; Frush, DP; Bogonad, P; Charles, HC; Ravin, CE
Published in: Radiology
September 1999

Four patients with cystic fibrosis (CF) were examined with combined hyperpolarized helium 3-enhanced and conventional proton magnetic resonance (MR) imaging. After inhalation of the polarized 3He gas, single breath-hold, gradient-echo images (resonant frequency of 3He) were obtained to depict lung ventilation. Conventional T2-weighted fast spin-echo (hydrogen) images were also obtained to depict morphologic abnormalities. 3He images were successfully and reproducibly generated that showed both morphologic abnormalities and, often more extensive, ventilation abnormalities. 3He MR imaging may provide a method for evaluating progression of pulmonary disease in patients with CF.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

September 1999

Volume

212

Issue

3

Start / End Page

885 / 889

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Image Enhancement
  • Humans
  • Helium
  • Female
 

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Donnelly, L. F., MacFall, J. R., McAdams, H. P., Majure, J. M., Smith, J., Frush, D. P., … Ravin, C. E. (1999). Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. Radiology, 212(3), 885–889. https://doi.org/10.1148/radiology.212.3.r99se20885
Donnelly, L. F., J. R. MacFall, H. P. McAdams, J. M. Majure, J. Smith, D. P. Frush, P. Bogonad, H. C. Charles, and C. E. Ravin. “Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.Radiology 212, no. 3 (September 1999): 885–89. https://doi.org/10.1148/radiology.212.3.r99se20885.
Donnelly LF, MacFall JR, McAdams HP, Majure JM, Smith J, Frush DP, et al. Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. Radiology. 1999 Sep;212(3):885–9.
Donnelly, L. F., et al. “Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.Radiology, vol. 212, no. 3, Sept. 1999, pp. 885–89. Pubmed, doi:10.1148/radiology.212.3.r99se20885.
Donnelly LF, MacFall JR, McAdams HP, Majure JM, Smith J, Frush DP, Bogonad P, Charles HC, Ravin CE. Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. Radiology. 1999 Sep;212(3):885–889.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

September 1999

Volume

212

Issue

3

Start / End Page

885 / 889

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Image Enhancement
  • Humans
  • Helium
  • Female