Proton spectroscopy of human brain: effects of age and sex.

Journal Article (Clinical Trial;Journal Article)

1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS.

Full Text

Duke Authors

Cited Authors

  • Charles, HC; Lazeyras, F; Krishnan, KR; Boyko, OB; Patterson, LJ; Doraiswamy, PM; McDonald, WM

Published Date

  • October 1994

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 995 - 1004

PubMed ID

  • 7824764

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/0278-5846(94)90125-2


  • eng

Conference Location

  • England