Human in vivo phosphate metabolite imaging with 31P NMR.

Published

Journal Article

Phosphorus (31P) spectroscopic images showing the distribution of high-energy phosphate metabolites in the human brain have been obtained at 1.5 T in scan times of 8.5 to 34 min at 27 and 64 cm3 spatial resolution using pulsed phase-encoding gradient magnetic fields and three-dimensional Fourier transform (3DFT) techniques. Data were acquired as free induction decays with a quadrature volume NMR detection coil of a truncated geometry designed to optimize the signal-to-noise ratio on the coil axis on the assumption that the sample noise represents the dominant noise source, and self-shielded magnetic field gradient coils to minimize eddy-current effects. The images permit comparison of metabolic data acquired simultaneously from different locations in the brain, as well as metabolite quantification by inclusion of a vial containing a standard of known 31P concentration in the image array. Values for the NMR visible adenosine triphosphate in three individuals were about 3 mM of tissue. The ratio of NMR detectable phosphocreatine to ATP in brain was 1.15 +/- 0.17 SD in these experiments. Potential sources of random and systematic error in these and other 31P measurements are identified.

Full Text

Duke Authors

Cited Authors

  • Bottomley, PA; Charles, HC; Roemer, PB; Flamig, D; Engeseth, H; Edelstein, WA; Mueller, OM

Published Date

  • July 1988

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 319 - 336

PubMed ID

  • 3205148

Pubmed Central ID

  • 3205148

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910070309

Language

  • eng

Conference Location

  • United States