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Depressive symptoms and prospective incidence of colorectal cancer in women.

Publication ,  Journal Article
Kroenke, CH; Bennett, GG; Fuchs, C; Giovannucci, E; Kawachi, I; Schernhammer, E; Holmes, MD; Kubzansky, LD
Published in: American journal of epidemiology
November 2005

The authors examined depressive symptoms and prospective incidence of colorectal cancer and distal colorectal adenomas in 81,612 women without prior cancer from the Nurses' Health Study; 400 cases of colorectal cancer and 680 distal colorectal adenomas accrued between 1992 and the year 2000. Depressive symptoms were assessed in 1992 and 1996 with the five-question Mental Health Index (MHI-5), a subscale of the Short-Form 36 health status survey. Scores ranged from 0 to 100, and women with scores between 0 and 52 were defined as having significant depressive symptomatology. The authors also created four categories across the range of Mental Health Index scores: 0-52, 53-75, 76-85, and 86-100 (referent). Cox proportional hazards models were used to analyze the extent of depressive symptoms and colorectal events. Analyses were stratified by body mass index. In multivariate analyses with updated exposure, women with the highest levels of depressive symptoms had an elevated risk of incident colorectal cancer (hazard ratio = 1.43, 95% confidence interval: 0.97, 2.11) compared with women with the lowest levels of symptoms (p(trend) = 0.04). Associations appeared stronger in overweight women. However, depressive symptoms were unrelated to risk of colorectal adenomas. Associations are consistent with a possible role in late promotion of the disease.

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Published In

American journal of epidemiology

DOI

EISSN

1476-6256

ISSN

0002-9262

Publication Date

November 2005

Volume

162

Issue

9

Start / End Page

839 / 848

Related Subject Headings

  • United States
  • Prospective Studies
  • Middle Aged
  • Incidence
  • Humans
  • Health Surveys
  • Follow-Up Studies
  • Female
  • Epidemiology
  • Depression
 

Citation

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ICMJE
MLA
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Kroenke, C. H., Bennett, G. G., Fuchs, C., Giovannucci, E., Kawachi, I., Schernhammer, E., … Kubzansky, L. D. (2005). Depressive symptoms and prospective incidence of colorectal cancer in women. American Journal of Epidemiology, 162(9), 839–848. https://doi.org/10.1093/aje/kwi302
Kroenke, Candyce H., Gary G. Bennett, Charles Fuchs, Ed Giovannucci, Ichiro Kawachi, Eva Schernhammer, Michelle D. Holmes, and Laura D. Kubzansky. “Depressive symptoms and prospective incidence of colorectal cancer in women.American Journal of Epidemiology 162, no. 9 (November 2005): 839–48. https://doi.org/10.1093/aje/kwi302.
Kroenke CH, Bennett GG, Fuchs C, Giovannucci E, Kawachi I, Schernhammer E, et al. Depressive symptoms and prospective incidence of colorectal cancer in women. American journal of epidemiology. 2005 Nov;162(9):839–48.
Kroenke, Candyce H., et al. “Depressive symptoms and prospective incidence of colorectal cancer in women.American Journal of Epidemiology, vol. 162, no. 9, Nov. 2005, pp. 839–48. Epmc, doi:10.1093/aje/kwi302.
Kroenke CH, Bennett GG, Fuchs C, Giovannucci E, Kawachi I, Schernhammer E, Holmes MD, Kubzansky LD. Depressive symptoms and prospective incidence of colorectal cancer in women. American journal of epidemiology. 2005 Nov;162(9):839–848.
Journal cover image

Published In

American journal of epidemiology

DOI

EISSN

1476-6256

ISSN

0002-9262

Publication Date

November 2005

Volume

162

Issue

9

Start / End Page

839 / 848

Related Subject Headings

  • United States
  • Prospective Studies
  • Middle Aged
  • Incidence
  • Humans
  • Health Surveys
  • Follow-Up Studies
  • Female
  • Epidemiology
  • Depression