Effects of OROS methylphenidate on academic, behavioral, and cognitive tasks in children 9 to 12 years of age with attention-deficit/hyperactivity disorder.


Journal Article

OBJECTIVE: To assess effects of OROS methylphenidate on cognitive and academic tasks in 9 to 12 year olds with attention-deficit/hyperactivity disorder (ADHD). METHODS: A double-blind, within-subject, crossover design was used to compare OROS methylphenidate with placebo in a laboratory classroom setting on several cognitive and academic tasks for 68 children who met randomization criteria. RESULTS: Performance on the following measures was significantly better when children received individually optimized OROS methylphenidate than placebo: math fluency and accuracy measured by the Permanent Product Math Test, ADHD symptoms observed in the laboratory setting, computerized indices of attention and impulsivity as measured by the Test of Variables of Attention (TOVA), and visual-spatial working memory (Finger Windows Backwards). Study medication was well tolerated; adverse events were generally consistent with previous reports. CONCLUSIONS: OROS methylphenidate improves performance on measures of attention and vigilance, behavior, and working memory in a laboratory school setting in 9 to 12 year olds with ADHD.

Full Text

Cited Authors

  • Murray, DW; Childress, A; Giblin, J; Williamson, D; Armstrong, R; Starr, HL

Published Date

  • April 2011

Published In

Volume / Issue

  • 50 / 4

Start / End Page

  • 308 - 320

PubMed ID

  • 21436147

Pubmed Central ID

  • 21436147

Electronic International Standard Serial Number (EISSN)

  • 1938-2707

International Standard Serial Number (ISSN)

  • 0009-9228

Digital Object Identifier (DOI)

  • 10.1177/0009922810394832


  • eng