A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.

Journal Article (Journal Article)

Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal mice were radiographically determined at end-inspiration and end-expiration and pulmonary compliance was calculated at 2 time points 2 weeks apart, whereas a second group of mice were given bleomycin and imaged 3 weeks following drug administration. Compliance measurements were validated using a commercially available ventilator system. MicroCT pulmonary compliance measurements are suitable for longitudinal measurements, and correlate with physiologic measurements of pulmonary compliance.

Full Text

Duke Authors

Cited Authors

  • Shofer, S; Badea, C; Auerbach, S; Schwartz, DA; Johnson, GA

Published Date

  • April 2007

Published In

Volume / Issue

  • 33 / 3-4

Start / End Page

  • 169 - 183

PubMed ID

  • 17558678

Pubmed Central ID

  • PMC2677683

International Standard Serial Number (ISSN)

  • 0190-2148

Digital Object Identifier (DOI)

  • 10.1080/01902140701364458


  • eng

Conference Location

  • England