Comparison of functional MR and H2 15O positron emission tomography in stimulation of the primary visual cortex.

Journal Article (Journal Article)

PURPOSE: To locate spoiled gradient-echo functional MR signal changes in relation to brain parenchyma. METHODS: The region of the primary visual cortex was evaluated using functional MR and H2 15O positron emission tomography in each of six male subjects who were being visually stimulated by means of red light-emitting diode flash goggles. RESULTS: The positron emission tomography technique demonstrated substantially greater relative signal change with visual stimulation than did the functional MR technique. Furthermore, the functional MR signal changes were concentrated in loci around the periphery of brain parenchyma exhibiting increased radiotracer activity, as opposed to being collocated. CONCLUSIONS: Signal changes found using functional MR based on gradient-echo techniques reflect primarily phenomena occurring within small veins and underrepresent activity intrinsic to brain parenchyma, thus introducing potential inaccuracies in locating regions of activated brain tissue. Positron emission tomography, however, directly measures changes in metabolically related activity within the parenchyma.

Full Text

Duke Authors

Cited Authors

  • Kraut, MA; Marenco, S; Soher, BJ; Wong, DF; Bryan, RN

Published Date

  • 1995

Published In

Volume / Issue

  • 16 / 10

Start / End Page

  • 2101 - 2107

PubMed ID

  • 8585501

Pubmed Central ID

  • PMC8337232

International Standard Serial Number (ISSN)

  • 0195-6108


  • eng

Conference Location

  • United States